[CPEO-MEF] Perchlorate metabolism in goats

[Lenny Siegel <lsiegel@cpeo.org>]

Title: Tissue Distribution, Elimination, and Metabolism of Sodium 
[36cl]perchlorate in Lactating Goats

Authors
Smith, David
Hakk, Heldur
Larsen, Gerald

Journal of Agriculture and Food Chemistry
Publication Acceptance Date: September 18, 2006


Interpretive Summary: Perchlorate is a strong oxidizing agent that 
occurs naturally at very low concentrations in ground waters. Several 
locations within the United States are contaminated with perchlorate 
from industrial sources, however. Because perchlorate at high doses can 
inhibit processes within the human thyroid gland, some in the scientific 
community have expressed concern that developing infants and children 
may be more sensitive to the effects of perchlorate than adults. This 
concern was accentuated with the discovery of perchlorate in commercial 
milk samples and in health supplements used by pregnant or nursing 
women. Therefore, a study was conducted to determine how much of a 
perchlorate dose is excreted in milk of dairy goats. Goats were used 
instead of cows because of the expense associated with the use of the 
radiolabeled perchlorate. We showed that although most of the 
perchlorate dosed to goats was converted to chloride (a component of 
table salt) prior to excretion, a significant proportion of the 
perchlorate was excreted intact into milk. The perchlorate was 
completely excreted in milk and urine within 72 hours of dosing, 
indicating that perchlorate does not tend to accumulate in lactating 
ruminants.


...

For the entire abstract, see
http://www.ars.usda.gov/research/publications/publications.htm?seq_no_115=198049
--


Lenny Siegel
Director, Center for Public Environmental Oversight
c/o PSC, 278-A Hope St., Mountain View, CA 94041
Voice: 650/961-8918 or 650/969-1545
Fax: 650/961-8918
<lsiegel@cpeo.org>
http://www.cpeo.org


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