[CPEO-MEF] PERCHLORATE: Imperial Valley (CA) biomonitoring

[Lenny Siegel <lennysiegel@gmail.com>]

Direct Measurement of Perchlorate Exposure Biomarkers in a Highly  
Exposed Population: A Pilot Study


Paul English, Ben Blount, et al
PLoS one
March 4, 2011

Abstract

Exposure to perchlorate is ubiquitous in the United States and has  
been found to be widespread in food and drinking water. People living  
in the lower Colorado River region may have perchlorate exposure  
because of perchlorate in ground water and locally-grown produce.  
Relatively high doses of perchlorate can inhibit iodine uptake and  
impair thyroid function, and thus could impair neurological  
development in utero. We examined human exposures to perchlorate in  
the Imperial Valley among individuals consuming locally grown produce  
and compared perchlorate exposure doses to state and federal  
reference doses. We collected 24-hour urine specimen from a  
convenience sample of 31 individuals and measured urinary excretion  
rates of perchlorate, thiocyanate, nitrate, and iodide. In addition,  
drinking water and local produce were also sampled for perchlorate.  
All but two of the water samples tested negative for perchlorate.  
Perchlorate levels in 79 produce samples ranged from non-detect to  
1816 ppb. Estimated perchlorate doses ranged from 0.02 to 0.51 µg/kg  
of body weight/day. Perchlorate dose increased with the number of  
servings of dairy products consumed and with estimated perchlorate  
levels in produce consumed. The geometric mean perchlorate dose was  
70% higher than for the NHANES reference population. Our sample of 31  
Imperial Valley residents had higher perchlorate dose levels compared  
with national reference ranges. Although none of our exposure  
estimates exceeded the U. S. EPA reference dose, three participants  
exceeded the acceptable daily dose as defined by bench mark dose  
methods used by the California Office of Environmental Health Hazard  
Assessment.

...

For the entire article, see
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048868/?tool=pubmed

--

Lenny Siegel
Executive Director, Center for Public Environmental Oversight
a project of the Pacific Studies Center
278-A Hope Street, Mountain View, CA 94041
Voice: 650-961-8918 or 650-969-1545
Fax: 650-961-8918
<lsiegel@cpeo.org>
http://www.cpeo.org

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